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T Cells of Multiple Sclerosis Patients Target a Common Environmental Peptide that Causes Encephalitis in Mice

Shawn Winer, Igor Astsaturov, Roy K. Cheung, Katrin Schrade, Lakshman Gunaratnam, Denise D. Wood, Mario A. Moscarello, Paul O’Connor, Colin McKerlie, Dorothy J. Becker, Hans-Michael Dosch
November 2005
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Summary

This article examines research related to t cells of multiple sclerosis patients target a common environmental peptide that causes encephalitis in mice. The study provides new insights into mechanisms and factors influencing MS pathogenesis. Multiple lines of evidence from animal models and human studies contribute to understanding disease progression. The research identifies potential therapeutic targets or preventive strategies for MS management. Key findings advance scientific knowledge about how environment, genetics, and biology interact in MS.